Technology Process of tert-butyl 3-hydroxy-3-vinylazetidine-1-carboxylate
There total 1 articles about tert-butyl 3-hydroxy-3-vinylazetidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
at -78 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol402127b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere; Schlenk technique; Reflux
1.2: 20 h / Inert atmosphere; Schlenk technique; Reflux
2.1: Grubbs catalyst first generation / toluene / 0.5 h / 20 °C / Inert atmosphere; Schlenk technique
2.2: 3.5 h / Inert atmosphere; Schlenk technique; Resolution of racemate
3.1: L-diisopinocampheylborane / tetrahydrofuran / 40 h / -78 - 50 °C / Inert atmosphere; Schlenk technique
3.2: 0.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / -25 °C / Inert atmosphere
5.1: hydrazine hydrate / methanol / 1 h / 20 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
With
Grubbs catalyst first generation; di-isopropyl azodicarboxylate; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; L-diisopinocampheylborane;
In
tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
4.1: |Mitsunobu Displacement;
DOI:10.1021/ol402127b
- Guidance literature:
-
tert-butyl 3-hydroxy-3-vinylazetidine-1-carboxylate;
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
Benzyl bromoacetate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201105235
