(E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

Base Information

Chemical Name:(E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate
CAS No.:1610701-87-5
Molecular Formula:C₁₈H₁₈O₄
Molecular Weight:298.339
Hs Code.:

Synonyms:

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Chemical Property of (E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

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Technology Process of (E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

There total 5 articles about (E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1428945-38-3
(E)-2,4-dihydroxy-6-(1-propenyl)benzoic acid methyl ester

: 100-39-0
benzyl bromide

: 1610701-87-5
(E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: With potassium carbonate; In acetone; for 16h; Inert atmosphere; Reflux;
DOI:10.1021/jo5008527

Reference yield:

: 185038-86-2
4-Benzyloxy-2-methoxy-6-trifluoromethanesulfonyloxy-benzoic acid methyl ester

: 1610701-87-5
(E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 24 h / 45 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

4: potassium carbonate / acetone / 16 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; potassium carbonate; lithium chloride; In tetrahydrofuran; dichloromethane; acetone; 1: |Stille Cross Coupling;
DOI:10.1021/jo5008527

Reference yield:

: 83-30-7
acide 2,4,6-trihydroxybenzoique

: 1610701-87-5
(E)-methyl 4-(benzyloxy)-6-hydroxy-2-(prop-1-en-1-yl)-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfate; potassium carbonate / acetone / 16 h / 20 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere; Reflux

2.1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 48 h / 80 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 24 h / 45 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 16 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; boron tribromide; potassium carbonate; dimethyl sulfate; lithium chloride; In tetrahydrofuran; dichloromethane; acetone; 2.1: |Stille Cross Coupling;
DOI:10.1021/jo5008527