5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

Base Information

Chemical Name:5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate
CAS No.:1380094-17-6
Molecular Formula:CH₄O₃S*C₂₃H₂₃F₂N₅O₂
Molecular Weight:535.572
Hs Code.:

5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

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Chemical Property of 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

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Technology Process of 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

There total 11 articles about 5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380094-23-4
(2S)-N-benzyl-4-methoxy-N-[(1S)-1-phenylethyl]butan-2-amine

: 1380094-17-6
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 40 h / Inert atmosphere

1.2: 0.5 h

2.1: hydrogenchloride / tetrahydrofuran; methanol / 5 h / 0 - 45 °C / Inert atmosphere

2.2: 8 h / 0 - 25 °C

3.1: ethanol / 16 h / 85 °C / Sealed vial

3.2: 85 °C

4.1: dichloromethane; methanol / 0.5 h / 20 °C

With hydrogenchloride; hydrogen; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1380094-29-0
1-(6-amino-S-nitro-2-pyridyl)-2-(2,4-difluorophenyl)ethane-1,2-dione

: 1380094-17-6
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed vial

2.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

2.2: 30 h / pH 8

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

4.1: ethanol / 16 h / 85 °C / Sealed vial

4.2: 85 °C

5.1: dichloromethane; methanol / 0.5 h / 20 °C

With sulfuric acid; ammonium acetate; hydrogen; sodium nitrite; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 27048-04-0
2-amino-6-chloro-3-nitropyridine

: 1380094-17-6
5-[2-cyclopropyl-5-(2,4-difluorophenyl)-1H-imidazol-4-yl]-N-[(1 S)-3-methoxy-1-methyl-propyl]oxazolo[5,4-b]pyridin-2-amine methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.17 h / 0 - 5 °C / Inert atmosphere

1.2: 1 h / 30 °C

2.1: disodium hydrogenphosphate; potassium permanganate; sodium dihydrogenphosphate / water; acetone / 5 h / 0 - 15 °C / Inert atmosphere

2.2: 1 h / 15 - 20 °C

3.1: ammonium acetate / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed vial

4.1: sodium nitrite; sulfuric acid / water; dimethyl sulfoxide / 1.5 h / 0 - 20 °C

4.2: 30 h / pH 8

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / Inert atmosphere

6.1: ethanol / 16 h / 85 °C / Sealed vial

6.2: 85 °C

7.1: dichloromethane; methanol / 0.5 h / 20 °C

With potassium permanganate; disodium hydrogenphosphate; sodium dihydrogenphosphate; sulfuric acid; ammonium acetate; hydrogen; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetone; acetonitrile;