(R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide

Base Information

Chemical Name:(R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide
CAS No.:770696-44-1
Molecular Formula:C₂₅H₃₇N₃O
Molecular Weight:395.588
Hs Code.:

Synonyms:

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Chemical Property of (R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide

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Technology Process of (R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide

There total 3 articles about (R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 770696-44-1
(R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl cyanophosphonate; Et₃N / CH₂Cl₂

2: 83 percent / 4.6 N HCl / ethyl acetate / 1 h / 20 °C

3: 87 percent / BH₃ / tetrahydrofuran / 4 h / Heating

4: diethyl cyanophosphonate; N-methylmorpholine / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; diethyl cyanophosphonate; borane; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Condensation / 2: deprotection / 3: Reduction / 4: Condensation;
DOI:10.1021/jm9806704

Reference yield:

: 256352-17-7
BOC-(R)-alanine-N-(4-benzyl-1-piperazinyl)carboxamide

: 770696-44-1
(R)-adamantane-1-carboxylic acid N-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 4.6 N HCl / ethyl acetate / 1 h / 20 °C

2: 87 percent / BH₃ / tetrahydrofuran / 4 h / Heating

3: diethyl cyanophosphonate; N-methylmorpholine / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; diethyl cyanophosphonate; borane; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: deprotection / 2: Reduction / 3: Condensation;
DOI:10.1021/jm9806704