6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione

Base Information

• Chemical Name: 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione
• CAS No.: 1381876-80-7
• Molecular Formula: C₁₈H₁₇NO₅
• Molecular Weight: 327.337
• Mol file: 1381876-80-7.mol

Synonyms:

Chemical Property of 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione

There total 6 articles about 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.8%

6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione (82218-06-2) + 4-methoxy-aniline (104-94-9) → 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione (1381876-80-7)

Guidance literature:

With acetic acid; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1007/s00044-013-0734-x

Reference yield:

3-(3,5-dimethoxyphenyl)acrylic acid (16909-11-8) → 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione (1381876-80-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 5%-palladium/activated carbon; hydrogen / methanol; tetrahydrofuran / 30 h / 20 °C

2: polyphosphoric acid / 5 h / 80 °C / Inert atmosphere

3: sodium methylate / methanol; toluene / 2 - 20 °C

4: potassium hydroxide; dihydrogen peroxide / water / 5 h / 2 - 50 °C

5: acetic anhydride / toluene / 7 h / 2 °C / Inert atmosphere; Reflux

6: acetic acid / 20 °C / Inert atmosphere; Reflux

With 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; sodium methylate; acetic anhydride; acetic acid; potassium hydroxide; In tetrahydrofuran; methanol; water; toluene;

DOI:10.1007/s00044-013-0734-x

Reference yield:

3-(3,5-dimethoxyphenyl)propionic acid (717-94-2) → 6,8-dimethoxy-2-(4-methoxyphenyl)isoquinoline-1,3(2H,4H)-dione (1381876-80-7)

Guidance literature:

Multi-step reaction with 5 steps

1: polyphosphoric acid / 5 h / 80 °C / Inert atmosphere

2: sodium methylate / methanol; toluene / 2 - 20 °C

3: potassium hydroxide; dihydrogen peroxide / water / 5 h / 2 - 50 °C

4: acetic anhydride / toluene / 7 h / 2 °C / Inert atmosphere; Reflux

5: acetic acid / 20 °C / Inert atmosphere; Reflux

With dihydrogen peroxide; sodium methylate; acetic anhydride; acetic acid; potassium hydroxide; In methanol; water; toluene;

DOI:10.1007/s00044-013-0734-x

upstream raw materials:

2-carboxymethyl-4,6-dimethoxy-benzoic acid

6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione

4-methoxy-aniline

3-(3,5-dimethoxyphenyl)propionic acid