C₂₁H₂₃NO₄

Base Information

• Chemical Name: C₂₁H₂₃NO₄
• CAS No.: 1417600-53-3
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.418
• Mol file: 1417600-53-3.mol

Synonyms:

Chemical Property of C₂₁H₂₃NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃NO₄

There total 7 articles about C₂₁H₂₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl α-N-benzyloxycarbonyl-α,β-didehydroprolinate + phenylboronic acid (98-80-6) → C21H23NO4 (1417600-53-3) + C21H23NO4

Guidance literature:

With 2-methyltetrahydrofuran; potassium phosphate; (-)-1,2-bis((2R,5R)-2,2-diphenylphospholano)ethane(1,5-cyclooctane)rhodium(I) tetrafluoroborate; at 60 ℃; Overall yield = 83 percent; enantioselective reaction;

DOI:10.1021/acscatal.0c04648

Reference yield:

ethyl 5,5-dimethoxy-2-nitro-3-phenylpentanoate → C21H23NO4 (1417600-53-3) + C21H23NO4

Guidance literature:

Multi-step reaction with 6 steps

1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 0.33 h / 0 °C

2: hydrogenchloride / methanol; water / 0.33 h / 70 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 20 °C

4: triethylamine / tetrahydrofuran / 12 h / 20 °C

5: lithium hydroxide; water / methanol; tetrahydrofuran / 23.5 h / 0 - 10 °C

6: thionyl chloride / Reflux

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1002/adsc.201200538

Reference yield:

ethyl 2-amino-3-phenyl-5,5-dimethoxypentanoate → C21H23NO4 (1417600-53-3) + C21H23NO4

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; water / 0.33 h / 70 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 20 °C

3: triethylamine / tetrahydrofuran / 12 h / 20 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 23.5 h / 0 - 10 °C

5: thionyl chloride / Reflux

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; water; hydrogen; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1002/adsc.201200538

upstream raw materials:

ethanol

(2R,3S)-1-((benzyloxy)carbonyl)-3-phenylpyrrolidine-2-carboxylic acid

phenylboronic acid