α-Diethylphosphinylphenylacetic acid hydrazide

Base Information

• Chemical Name: α-Diethylphosphinylphenylacetic acid hydrazide
• CAS No.: 82460-65-9
• Molecular Formula: C₁₂H₁₉N₂O₂P
• Molecular Weight: 254.269
• Mol file: 82460-65-9.mol

Synonyms:

Chemical Property of α-Diethylphosphinylphenylacetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Diethylphosphinylphenylacetic acid hydrazide

There total 3 articles about α-Diethylphosphinylphenylacetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Ethyl α-diethylphosphinylphenylacetate (82460-64-8) → α-Diethylphosphinylphenylacetic acid hydrazide (82460-65-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Heating;

DOI:10.1007/BF00777269

Reference yield:

ethyl 2-chloro-2-phenylacetate (10606-73-2,99531-04-1,116836-53-4,4773-33-5) → α-Diethylphosphinylphenylacetic acid hydrazide (82460-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / 3 h / 80 °C

2: 67 percent / hydrazine hydrate / ethanol / 3 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1007/BF00777269

Reference yield:

ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) → α-Diethylphosphinylphenylacetic acid hydrazide (82460-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / 3 h / 60 - 70 °C

2: 67 percent / hydrazine hydrate / ethanol / 3 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1007/BF00777269

upstream raw materials:

Ethyl α-diethylphosphinylphenylacetate

ethyl 2-chloro-2-phenylacetate

ethyl 2-phenyl-2-bromoacetate