(1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Base Information

Chemical Name:(1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester
CAS No.:132047-84-8
Molecular Formula:C₂₃H₃₂O₄
Molecular Weight:372.505
Hs Code.:

Synonyms:

Suppliers and Price of (1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

There total 18 articles about (1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100818-74-4
2,3-dideoxy-5,6-O-(1-methylethylidene)-4-O-bnezyl-D-erythro-hexitol

: 132047-84-8
(1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) MsCl, Et₃N / 2.) Bu₄NI / 1.) 0 deg C, 2.) DMF, 80 deg C

2: 1.) CH₃COOH, CH₃OH, 2.) NaIO₄ / 1.) reflux 2.) THF, H₂O

4: 67 percent / LDA / tetrahydrofuran / -78 - 23 °C

5: 1.) DIBAL-H / 1.) toluene, -78 deg C, 2.) CH₂Cl₂, RT

7: 86 percent / 5percent Na/Hg / methanol / 24 h / 23 °C

8: NiCl₂*6H₂O, NaBH₄ / methanol / 1.5 h / 0 - 23 °C

With methanol; sodium tetrahydroborate; sodium periodate; sodium amalgam; diisobutylaluminium hydride; acetic acid; methanesulfonyl chloride; triethylamine; nickel dichloride; lithium diisopropyl amide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)98725-2

Reference yield:

: 87604-53-3
(R)-4-((S)-1-(benzyloxy)but-3-ene-1-yl)-2,2-dimethyl-1,3-dioxypentane

: 132047-84-8
(1R,2R,4aS,5S,8aR)-5-Benzyloxy-2-(3-hydroxy-propyl)-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) BH₃ 2.) 3M NaOH, 30 percent H₂O₂ / 1.) THF, 0 deg C

2: 1.) MsCl, Et₃N / 2.) Bu₄NI / 1.) 0 deg C, 2.) DMF, 80 deg C

3: 1.) CH₃COOH, CH₃OH, 2.) NaIO₄ / 1.) reflux 2.) THF, H₂O

5: 67 percent / LDA / tetrahydrofuran / -78 - 23 °C

6: 1.) DIBAL-H / 1.) toluene, -78 deg C, 2.) CH₂Cl₂, RT

8: 86 percent / 5percent Na/Hg / methanol / 24 h / 23 °C

9: NiCl₂*6H₂O, NaBH₄ / methanol / 1.5 h / 0 - 23 °C

With methanol; sodium hydroxide; sodium tetrahydroborate; sodium periodate; sodium amalgam; borane; dihydrogen peroxide; diisobutylaluminium hydride; acetic acid; methanesulfonyl chloride; triethylamine; nickel dichloride; lithium diisopropyl amide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(00)98725-2