N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea

Base Information

• Chemical Name: N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea
• CAS No.: 118438-63-4
• Molecular Formula: C₁₆H₁₃N₃O₃
• Molecular Weight: 295.298
• Mol file: 118438-63-4.mol

Synonyms:

Chemical Property of N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea

There total 1 articles about N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-cyanodiphenylcarbonimidate (79463-77-7) + 2-carbomethoxyaniline (134-20-3) → N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea (118438-63-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) dioxane, 2.) dioxane, 15 h;

DOI:10.1021/jo00266a013

Reference yield: 79.0%

N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea (118438-63-4) + benzylamine (100-46-9) → 3-benzyl-2-(cyanoimino)-4-oxo-1,2,3,4-tetrahydroquinazoline (118438-64-5)

Guidance literature:

In isopropyl alcohol; for 2h; Heating;

DOI:10.1021/jo00266a013

Reference yield:

N-(2-carbomethoxyphenyl)-N'-cyano-O-phenylisourea (118438-63-4) → 2-Amino-3-benzyl-3H-quinazolin-4-one; hydrochloride (118438-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / propan-2-ol / 2 h / Heating

2: 81 percent / conc. HCl / dimethylsulfoxide / 6 h / Heating

With hydrogenchloride; In dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1021/jo00266a013

upstream raw materials:

N-cyanodiphenylcarbonimidate

2-carbomethoxyaniline

Downstream raw materials:

3-benzyl-2-(cyanoimino)-4-oxo-1,2,3,4-tetrahydroquinazoline

2-Amino-3-benzyl-3H-quinazolin-4-one; hydrochloride

2-amino-3-benzyl-4-oxo-3,4-dihydro-quinazoline

Refernces