L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, 1-(1,1-dimethylethyl) 5-methyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, 1-(1,1-dimethylethyl) 5-methyl ester
CAS No.:105590-81-6
Molecular Formula:C₃₅H₅₂ClN₅O₉
Molecular Weight:722.279
Hs Code.:
Mol file:105590-81-6.mol

Synonyms:

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Chemical Property of L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, 1-(1,1-dimethylethyl) 5-methyl ester

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, 1-(1,1-dimethylethyl) 5-methyl ester

There total 7 articles about L-Glutamic acid, N-[N-[N-[N-[1-(4-chlorobenzoyl)-L-prolyl]-L-valyl]-2-methylalanyl]-2-methyl alanyl]-, 1-(1,1-dimethylethyl) 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 21368-28-5
4-chlorobenzoyl azide

: 105590-80-5
(S)-2-[2-Methyl-2-(2-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-propionylamino)-propionylamino]-pentanedioic acid 1-tert-butyl ester 5-methyl ester

: 105590-81-6
(S)-2-{2-[2-((S)-2-{[(S)-1-(4-Chloro-benzoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-pentanedioic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 1676-73-9,25014-27-1
L-glutamic acid γ-benzyl ester

: 105590-81-6
(S)-2-{2-[2-((S)-2-{[(S)-1-(4-Chloro-benzoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-pentanedioic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) cc. H₂SO₄; 2.) HCl / 1.) dioxane, 20 deg C, 4 d; 2.) ether, -10 deg C

2: 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) PhMe, 20 deg C, 15 min; 2.) PhMe, 50 deg C, 72 h

3: H₂ / 5percent Pd/C / methanol / 40 h / 20 °C / 3.5 kg cm^-2

4: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

5: 60 percent / tetrahydrofuran / 72 h / 20 °C

With hydrogenchloride; sulfuric acid; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 71890-87-4
N-phenylmethoxycarbonyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanine

: 105590-81-6
(S)-2-{2-[2-((S)-2-{[(S)-1-(4-Chloro-benzoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-pentanedioic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine; 2.) 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) / 1.) PhMe, 20 deg C, 15 min; 2.) PhMe, 50 deg C, 72 h

2: H₂ / 5percent Pd/C / methanol / 40 h / 20 °C / 3.5 kg cm^-2

3: tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

4: 60 percent / tetrahydrofuran / 72 h / 20 °C

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether;