Technology Process of C13H16N2O2
There total 5 articles about C13H16N2O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S)-2-(anilinomethyl)pyrrolidine;
With
hydrogenchloride;
In
methanol; diethyl ether;
for 0.0833333h;
orthoformic acid triethyl ester;
In
methanol; diethyl ether; toluene;
at 80 ℃;
for 12h;
With
potassium hexafluorophosphate;
In
water;
DOI:10.1055/s-0033-1340215
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine; chloroformic acid ethyl ester / ethyl acetate / 15 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 15 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Reflux; Inert atmosphere; Schlenk technique
4.1: hydrogenchloride / diethyl ether; methanol / 0.08 h
4.2: 12 h / 80 °C
With
4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; chloroformic acid ethyl ester;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate;
DOI:10.1055/s-0033-1340215
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol / 15 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 15 h / Reflux; Inert atmosphere; Schlenk technique
3.1: hydrogenchloride / diethyl ether; methanol / 0.08 h
3.2: 12 h / 80 °C
With
hydrogenchloride; lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1055/s-0033-1340215
