acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester
CAS No.:289676-31-9
Molecular Formula:C₃₃H₃₂N₆O₉
Molecular Weight:656.652
Hs Code.:

acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1<i>H</i>-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Synonyms:

Suppliers and Price of acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

There total 9 articles about acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: acetic acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methoxy-tetrahydro-furan-3-yl ester

: 289676-31-9
acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: With trichloroacetic acid; In dichloromethane; for 2h;
DOI:10.1016/S0960-894X(00)00226-2

Reference yield:

: 2140-76-3
2'-O-methyluridine

: 289676-31-9
acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / pyridine

2: 100 percent / I₂; ceric ammonium nitrate

3: 89 percent / CuI; (Ph₃P)4P; Et₃N / dimethylformamide / 16 h

4: aq. NH₃ / 16 h / 4 °C

5: EDC*HCl / dimethylformamide / 16 h

6: pyridine / 16 h

7: pyridine / 2 h

8: TCA / CH₂Cl₂ / 2 h

With pyridine; ammonium hydroxide; copper(l) iodide; ammonium cerium(IV) nitrate; (Ph₃P)4P; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichloroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Iodination / 3: Substitution / 4: ammonolysis / 5: Condensation / 6: tritylation / 7: Acetylation / 8: acidolysis;
DOI:10.1016/S0960-894X(00)00226-2

Reference yield:

: 61671-79-2
3',5'-di-O-acetyl-2'-O-methyluridine

: 289676-31-9
acetic acid 5-(5-{3-[2-(1-diphenylcarbamoyl-1H-imidazol-4-yl)-acetylamino]-prop-1-ynyl}-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-methoxy-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / I₂; ceric ammonium nitrate

2: 89 percent / CuI; (Ph₃P)4P; Et₃N / dimethylformamide / 16 h

3: aq. NH₃ / 16 h / 4 °C

4: EDC*HCl / dimethylformamide / 16 h

5: pyridine / 16 h

6: pyridine / 2 h

7: TCA / CH₂Cl₂ / 2 h

With pyridine; ammonium hydroxide; copper(l) iodide; ammonium cerium(IV) nitrate; (Ph₃P)4P; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichloroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Iodination / 2: Substitution / 3: ammonolysis / 4: Condensation / 5: tritylation / 6: Acetylation / 7: acidolysis;
DOI:10.1016/S0960-894X(00)00226-2