Technology Process of 6-fluoro-2-(octyloxy)-3-(pyridin-2-yl)benzonitrile
There total 5 articles about 6-fluoro-2-(octyloxy)-3-(pyridin-2-yl)benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
for 16h;
Reflux;
DOI:10.1021/jo200357e
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dimethyl sulfoxide; toluene / 4 h / Reflux
2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere
3: potassium hydroxide / 1,4-dioxane; water / 1 h / Reflux
4: potassium carbonate / acetonitrile / 16 h / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; potassium carbonate; potassium hydroxide;
In
1,4-dioxane; water; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jo200357e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / 1,4-dioxane; water / 20 h / 65 °C / Inert atmosphere
2: potassium hydroxide / 1,4-dioxane; water / 1 h / Reflux
3: potassium carbonate / acetonitrile / 16 h / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; potassium carbonate; potassium hydroxide;
In
1,4-dioxane; water; acetonitrile;
DOI:10.1021/jo200357e
