2,6-Difluoro-3-(2-pyridnyl)-benzonitrile

Base Information

• Chemical Name: 2,6-Difluoro-3-(2-pyridnyl)-benzonitrile
• CAS No.: 883106-18-1
• Molecular Formula: C12H6F2N2
• Molecular Weight: 216.19
• Mol file: 883106-18-1.mol

Synonyms:2,6-Difluoro-3-(2-pyridinyl)benzonitrile;5'-cyano-4',6'-difluoro-2-phenylpyridine;2,6-Difluoro-3-(pyridin-2-yl)benzonitrile;

Chemical Property of 2,6-Difluoro-3-(2-pyridnyl)-benzonitrile

Chemical Property:

• Melting Point: 76-77℃
• Boiling Point: 314.9±42.0 °C(Predicted)
• PKA: 3.25±0.29(Predicted)
• PSA: 36.68000
• Density: 1.32
• LogP: 2.89848
• Storage Temp.: 2-8°C

Purity/Quality:

99.0% ^*data from raw suppliers

2,6-Difluoro-3-(pyridin-2-yl)benzonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-3-(2-pyridnyl)-benzonitrile

There total 5 articles about 2,6-Difluoro-3-(2-pyridnyl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-iodopyridine (5029-67-4) + 2,4-difluoro-3-cyanophenylboronic acid (871940-31-7) → 2,6-difluoro-3-(pyridine-2-yl)benzonitrile (883106-18-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In ethanol; water; benzene; for 18h; Reflux; Inert atmosphere;

Reference yield: 73.18%

2-bromo-pyridine (109-04-6) + 2,4-difluoro-3-cyanophenylboronic acid (871940-31-7) → 2,6-difluoro-3-(pyridine-2-yl)benzonitrile (883106-18-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; at 65 ℃; for 24h;

Reference yield: 73.0%

2-bromo-pyridine (109-04-6) + 2,6-difluoro-3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzonitrile (1308400-81-8) → 2,6-difluoro-3-(pyridine-2-yl)benzonitrile (883106-18-1)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 65 ℃; for 20h; Inert atmosphere;

DOI:10.1021/jo200357e

upstream raw materials:

2-bromo-pyridine

2,6-difluoro-3-(6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocan-2-yl)benzonitrile

2,4-difluoro-3-cyanophenylboronic acid

2,6 difluorobenzonitrile

Downstream raw materials:

6-fluoro-2-hydroxy-3-(pyridin-2-yl)benzonitrile

2-fluoro-6-hydroxy-3-(pyridin-2-yl)benzonitrile

2,6-difluoro-3-(pyridin-2-yl)benzamide

6-fluoro-2-(octyloxy)-3-(pyridin-2-yl)benzonitrile