Technology Process of (4aR,11bS)-5-Benzyl-1,4,4a,5,6,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-3-one
There total 13 articles about (4aR,11bS)-5-Benzyl-1,4,4a,5,6,11b-hexahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 29.1 percent / 85percent MCPBA / CH2Cl2 / 720 h / 0 °C
2: 1) H2; 2) LiAlH4 / 1) Raney Ni / 1) EtOH, 50 deg C, 6 h; 2) THF, Et2O, 2 h
3: 67.2 percent / CH2Cl2 / 1) 2 days, room temperature; 2) 4.5 h, reflux
4: 91.5 percent / 5percent KOH / methanol / 0.75 h / Heating
5: 68.2 percent / CrO3-pyridine / Ambient temperature
6: 89.6 percent / BF3*Et2O / tetrahydrofuran / Ambient temperature
7: 71.8 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
8: 2) 6N HCl / 1) MeOH, room temperature, 5 min; 2) 2 h, room temperature
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; chromium trioxide-pyridine complex; boron trifluoride diethyl etherate; hydrogen; 3-chloro-benzenecarboperoxoic acid;
nickel;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)91130-5
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) H2; 2) LiAlH4 / 1) Raney Ni / 1) EtOH, 50 deg C, 6 h; 2) THF, Et2O, 2 h
2: 67.2 percent / CH2Cl2 / 1) 2 days, room temperature; 2) 4.5 h, reflux
3: 91.5 percent / 5percent KOH / methanol / 0.75 h / Heating
4: 68.2 percent / CrO3-pyridine / Ambient temperature
5: 89.6 percent / BF3*Et2O / tetrahydrofuran / Ambient temperature
6: 71.8 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
7: 2) 6N HCl / 1) MeOH, room temperature, 5 min; 2) 2 h, room temperature
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; chromium trioxide-pyridine complex; boron trifluoride diethyl etherate; hydrogen;
nickel;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)91130-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 67.2 percent / CH2Cl2 / 1) 2 days, room temperature; 2) 4.5 h, reflux
2: 91.5 percent / 5percent KOH / methanol / 0.75 h / Heating
3: 68.2 percent / CrO3-pyridine / Ambient temperature
4: 89.6 percent / BF3*Et2O / tetrahydrofuran / Ambient temperature
5: 71.8 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
6: 2) 6N HCl / 1) MeOH, room temperature, 5 min; 2) 2 h, room temperature
With
hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; chromium trioxide-pyridine complex; boron trifluoride diethyl etherate;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)91130-5
