Technology Process of (E)-(2R,3S)-6-Benzyloxy-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-hex-4-enal
There total 8 articles about (E)-(2R,3S)-6-Benzyloxy-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-hex-4-enal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / Et3N / CH2Cl2 / 0.33 h / 0 - 20 °C
2: 83 percent / DDQ, H2O / CH2Cl2
3: 1.) DMSO, oxalyl chloride, 2.) Et3N
With
oxalyl dichloride; water; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
DOI:10.1021/jo00075a024
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / NaH / dimethylformamide / 2 h / -40 - 0 °C
2: 90 percent / 90percent aq. AcOH / methanol / 10 h / 85 °C
3: 99 percent / Et3N / CH2Cl2 / 0.33 h / 0 - 20 °C
4: 83 percent / DDQ, H2O / CH2Cl2
5: 1.) DMSO, oxalyl chloride, 2.) Et3N
With
oxalyl dichloride; water; sodium hydride; acetic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00075a024
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72 percent / DIBAL / hexane; tetrahydrofuran / 3 h / -78 °C
2: 90 percent / NaH / dimethylformamide / 2 h / -40 - 0 °C
3: 90 percent / 90percent aq. AcOH / methanol / 10 h / 85 °C
4: 99 percent / Et3N / CH2Cl2 / 0.33 h / 0 - 20 °C
5: 83 percent / DDQ, H2O / CH2Cl2
6: 1.) DMSO, oxalyl chloride, 2.) Et3N
With
oxalyl dichloride; water; sodium hydride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00075a024
