1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate

Base Information

• Chemical Name: 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate
• CAS No.: 1350722-53-0
• Molecular Formula: C₂HF₃O₂*C₂₂H₃₀N₄O₅
• Molecular Weight: 544.528
• Mol file: 1350722-53-0.mol

Synonyms:

Chemical Property of 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate

There total 3 articles about 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide (747414-21-7) → 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate (1350722-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

2: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

3: triethylamine / dichloromethane / 5 h / Inert atmosphere

4: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

With water; nitric acid; acetic anhydride; boron trichloride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm201155e

Reference yield:

5-[2,4-bis(benzyloxy)-5-isopropylphenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide (1202920-71-5) → 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate (1350722-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: water; ammonium chloride; zinc / tetrahydrofuran / 0.75 h / 0 °C

2: triethylamine / dichloromethane / 5 h / Inert atmosphere

3: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

With water; boron trichloride; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm201155e

Reference yield:

4-amino-5-[2,4-bis(benzyloxy)-5-isopropylphenyl]isoxazole-3-carboxylic acid ethylamide (1202920-72-6) + 1-methylpiperidine-4-carboxylic acid chloride (41776-24-3) → 1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate (1350722-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 5 h / Inert atmosphere

2: boron trichloride / dichloromethane / 1.17 h / 0 - 20 °C / Inert atmosphere

With boron trichloride; triethylamine; In dichloromethane;

DOI:10.1021/jm201155e

upstream raw materials:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide

5-[2,4-bis(benzyloxy)-5-isopropylphenyl]-4-nitroisoxazole-3-carboxylic acid ethylamide

4-amino-5-[2,4-bis(benzyloxy)-5-isopropylphenyl]isoxazole-3-carboxylic acid ethylamide

1-methylpiperidine-4-carboxylic acid chloride