5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxaMide

Base Information

• Chemical Name: 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxaMide
• CAS No.: 747414-21-7
• Molecular Formula: C₂₉H₃₀N₂O₄
• Molecular Weight: 470.568
• Mol file: 747414-21-7.mol

Synonyms:5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide

Chemical Property of 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxaMide

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxaMide

There total 9 articles about 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-N-ethylisoxazole-3-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethyl ester (747414-20-6) + ethylamine (75-04-7,85404-22-4) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide (747414-21-7)

Guidance literature:

In ethanol; at 80 ℃; for 1h;

Reference yield:

2,4-dihydroxy-1-isopropylbenzene (23504-03-2) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide (747414-21-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: boron trifluoride diethyl etherate

2.1: potassium carbonate / acetonitrile / 20 °C

3.1: sodium ethanolate / ethanol / 20 °C

3.2: 20 °C

4.1: hydroxylamine hydrochloride / ethanol / 20 °C

5.1: ethanol; water / 5 h / Reflux

With boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium ethanolate; potassium carbonate; In ethanol; water; acetonitrile; 1.1: |Friedel-Crafts Acylation;

DOI:10.1016/j.bmcl.2015.06.009

Reference yield:

1-(2,4-dihydroxy-5-isopropylphenyl)ethan-1-one (747414-17-1) → 5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethylamide (747414-21-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 20 °C

2.1: sodium ethanolate / ethanol / 20 °C

2.2: 20 °C

3.1: hydroxylamine hydrochloride / ethanol / 20 °C

4.1: ethanol; water / 5 h / Reflux

With hydroxylamine hydrochloride; sodium ethanolate; potassium carbonate; In ethanol; water; acetonitrile;

DOI:10.1016/j.bmcl.2015.06.009

upstream raw materials:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)isoxazole-3-carboxylic acid ethyl ester

ethylamine

2',4'-dihydroxy-4-acetophenone

(((4-(prop-1-en-2-yl)-1,3-phenylene)bis(oxy))bis(methylene))dibenzene

Downstream raw materials:

5-(2,4-bis(benzyloxy)-5-isopropylphenyl)-4-iodoisoxazole-3-carboxylic acid ethylamide

1-methylpiperidine-4-carboxylic acid [5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-yl]amide trifluoroacetate

5-(2,4-dihydroxy-5-isopropylphenyl)-4-[(trans-4-methylaminomethylcyclohexanecarbonyl)amino]isoxazole-3-carboxylic acid ethylamide trifluoroacetate

(1S,3R)-3-[5-(2,4-dihydroxy-5-isopropylphenyl)-3-ethylcarbamoylisoxazol-4-ylcarbamoyl]cyclopentanecarboxylic acid methyl ester