Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Base Information

Chemical Name:Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me
CAS No.:1364705-55-4
Molecular Formula:C₃₁H₃₂ClN₃O₆
Molecular Weight:578.065
Hs Code.:

Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO<sub>2</sub>Me

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Chemical Property of Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

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Technology Process of Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

There total 12 articles about Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₀ClN₃O₅*ClH

: 108-24-7
acetic anhydride

: 1364705-55-4
Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo202105v

Reference yield:

: 851967-77-6
methyl (2S)-3-(3-chlorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate

: 1364705-55-4
Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine / hexane / 16 h / Inert atmosphere; Reflux

2.1: lithium hydrochloride monohydrate / methanol; water / 0.67 h / 20 °C / Inert atmosphere

2.2: pH 2 / Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; lithium hydrochloride monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v

Reference yield:

: 942070-92-0
methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate

: 1364705-55-4
Ac-(cyclo-m,m)-[(3-Cl)FAY]-CO₂Me

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydrochloride monohydrate / methanol; water / 0.67 h / 20 °C / Inert atmosphere

1.2: pH 2 / Inert atmosphere

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; cesium fluoride / 1,4-dioxane; water / 18 h / 90 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydrochloride monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki-Miyaura cyclization;
DOI:10.1021/jo202105v