C₃₀H₃₆FN₃O₅

Base Information

• Chemical Name: C₃₀H₃₆FN₃O₅
• CAS No.: 1268819-40-4
• Molecular Formula: C₃₀H₃₆FN₃O₅
• Molecular Weight: 537.631
• Mol file: 1268819-40-4.mol

Synonyms:

Chemical Property of C₃₀H₃₆FN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₆FN₃O₅

There total 4 articles about C₃₀H₃₆FN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H32N2O6 (1268819-53-9) + 4-fluoroaniline (371-40-4) → C30H36FN3O5 (1268819-40-4)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 - 25 ℃; for 16h;

DOI:10.1016/j.bmcl.2010.11.102

Reference yield:

C25H34N2O6 (1268819-52-8) → C30H36FN3O5 (1268819-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / 1,4-dioxane / 5 h / 25 °C

2: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 16 h / 0 - 25 °C

With water; chloroformic acid ethyl ester; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2010.11.102

Reference yield:

(S)-1-tert-butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate (84348-39-0) → C30H36FN3O5 (1268819-40-4)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine; trifluoroacetic acid / dichloromethane / 0.5 h

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 25 °C

3: water; lithium hydroxide / 1,4-dioxane / 5 h / 25 °C

4: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 16 h / 0 - 25 °C

With 4-methyl-morpholine; water; chloroformic acid ethyl ester; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2010.11.102

upstream raw materials:

C₂₅H₃₄N₂O₆

C₂₄H₃₂N₂O₆

4-fluoroaniline

(S)-1-tert-butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate

Downstream raw materials:

C₂₂H₂₈FN₃O₄