1,5:3,6-dianhydro-D-mannitol

Base Information

• Chemical Name: 1,5:3,6-dianhydro-D-mannitol
• CAS No.: 148706-62-1
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.143
• Mol file: 148706-62-1.mol

Synonyms:

Chemical Property of 1,5:3,6-dianhydro-D-mannitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5:3,6-dianhydro-D-mannitol

There total 1 articles about 1,5:3,6-dianhydro-D-mannitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mannitol (69-65-8) → 1,6-dichloro-2S,3S,4S,5S-hexanetetraol (7251-85-6,58073-31-7) + 1,5:3,6-dianhydro-D-mannitol (148706-62-1) + 1,4-anhydro-D-mannitol (7726-97-8) + 1,5-anhydro-D-mannitol (492-93-3,53319-04-3)

Guidance literature:

at 100 ℃; weitereProd_.:Dianhydrohexit;1-Chlor-3.6-anhydro-1-desoxy-D-mannit;2-Chlor-1.4;3.6-dianhydro-2-desoxy-D-mannit;Dichloranhydro-didesoxy-mannit;

DOI:10.1039/jr9470000433

Reference yield:

1,5:3,6-dianhydro-D-mannitol (148706-62-1) → 1,5:3,6-dianhydro-4-O-benzyl-1,2-dideoxy-2-O-(tert-butyldimethylsilyl)-D-arabinohexose (152492-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, 2.) tetra-n-butylammonium iodide / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 2 h

2: 95 percent / 4 Angstroem sieves, tetra-n-propylammonium perruthenate (TPAP), N-methylmorpholine N-oxide (NMMO) / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 56 percent / KH / tetrahydrofuran / 20 h

With tetrapropylammonium perruthennate; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane;

Reference yield:

1,5:3,6-dianhydro-D-mannitol (148706-62-1) → 1,5:3,6-dianhydro-4-O-benzyl-D-arabinohexulose (148706-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) tetra-n-butylammonium iodide / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 2 h

2: 95 percent / 4 Angstroem sieves, tetra-n-propylammonium perruthenate (TPAP), N-methylmorpholine N-oxide (NMMO) / CH₂Cl₂ / 0.25 h / Ambient temperature

With tetrapropylammonium perruthennate; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; sodium hydride; 4-methylmorpholine N-oxide; In dichloromethane;

upstream raw materials:

mannitol

Downstream raw materials:

1,5:3,6-dianhydro-4-O-benzyl-D-mannitol

1,5:3,6-dianhydro-4-O-benzyl-1,2-dideoxy-2-O-(tert-butyldimethylsilyl)-D-arabinohexose

1,5:3,6-dianhydro-4-O-benzyl-D-arabinohexulose