3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

Base Information

Chemical Name:3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide
CAS No.:1445984-46-2
Molecular Formula:C₃₂H₄₁Cl₂FN₄O₇
Molecular Weight:683.605
Hs Code.:

3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

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Chemical Property of 3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

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Technology Process of 3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

There total 8 articles about 3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 488-43-7
1-Amino-1-deoxy-D-glucitol

: C₂₆H₂₈Cl₂FN₃O₃

: 1445984-46-2
3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445984-46-2
3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: sodium hydroxide / dichloromethane; water / 1 h / 0 °C

3: sodium tetrahydroborate / methanol / 1 h / 20 °C

4: hydrogen; rhodium contaminated with carbon / ethyl acetate / 20 °C

5: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 2 h / 0 °C

6: potassium carbonate / acetonitrile / 20 °C

7: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

8: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With chromium(VI) oxide; sodium tetrahydroborate; N-Bromosuccinimide; trimethylsilyl bromide; sulfuric acid; rhodium contaminated with carbon; hydrogen; acetic anhydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: C₃₀H₃₆Cl₂FN₃O₃

: 1445984-46-2
3-(2,5-dichloro-4-(((2S,4S)-2-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl)methyl)phenyl)-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl bromide / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.8b00308