C₃₂H₃₇N₉O

Base Information

• Chemical Name: C₃₂H₃₇N₉O
• CAS No.: 1383481-70-6
• Molecular Formula: C₃₂H₃₇N₉O
• Molecular Weight: 563.705
• Mol file: 1383481-70-6.mol

Synonyms:

Chemical Property of C₃₂H₃₇N₉O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₇N₉O

There total 6 articles about C₃₂H₃₇N₉O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H18N4O (652139-92-9) + C21H20ClN5 (1383481-65-9) → C32H37N9O (1383481-70-6)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 140 ℃; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.04.085

Reference yield:

[2-chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-cyclopentyl amine (1211442-87-3) → C32H37N9O (1383481-70-6)

Guidance literature:

Multi-step reaction with 5 steps

1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: N-iodo-succinimide; silver nitrate / N,N-dimethyl-formamide

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 80 °C

5: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 140 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira coupling / 4: Suzuki coupling;

DOI:10.1016/j.bmcl.2012.04.085

Reference yield:

2-chloro-N-cyclopentyl-5-((trimethylsilyl)ethynyl)pyrimidin -4-amine (1383481-56-8) → C32H37N9O (1383481-70-6)

Guidance literature:

Multi-step reaction with 4 steps

1: N-iodo-succinimide; silver nitrate / N,N-dimethyl-formamide

2: tetrabutyl ammonium fluoride / tetrahydrofuran

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 80 °C

4: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 140 °C / Microwave irradiation

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; silver nitrate; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2012.04.085

upstream raw materials:

5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

[2-chloro-5-(3,3-diethoxy-prop-1-ynyl)-pyrimidin-4-yl]-cyclopentyl amine

2-chloro-N-cyclopentyl-5-((trimethylsilyl)ethynyl)pyrimidin -4-amine

C₁₁H₁₁ClIN₃