2-Quinolinamine, 4-methyl-N-phenyl-

Base Information

• Chemical Name: 2-Quinolinamine, 4-methyl-N-phenyl-
• CAS No.: 10562-04-6
• Molecular Formula: C16H14N2
• Molecular Weight: 234.301
• Mol file: 10562-04-6.mol

Synonyms:

Chemical Property of 2-Quinolinamine, 4-methyl-N-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Quinolinamine, 4-methyl-N-phenyl-

There total 11 articles about 2-Quinolinamine, 4-methyl-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-4-methylquinoline (634-47-9) + aniline (62-53-3) → 4-methyl-N-phenylquinolin-2-amine (10562-04-6)

Guidance literature:

With C₄₈H₅₆ClN₃Pd; potassium tert-butylate; In tetrahydrofuran; at 70 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/asia.201700877

Reference yield: 85.0%

N-phenyl-N'-2-isopropenylphenylthiourea → 4-methyl-N-phenylquinolin-2-amine (10562-04-6)

Guidance literature:

With mercury(II) oxide; In dichloromethane; for 24h;

Reference yield: 65.0%

2-isopropenylaniline (52562-19-3) + phenyl isothiocyanate (103-72-0) → 4-methyl-N-phenylquinolin-2-amine (10562-04-6)

Guidance literature:

With potassium phosphate; In 1,4-dioxane; at 100 ℃; for 12h; chemoselective reaction;

DOI:10.1039/c8cc00062j

upstream raw materials:

2-chloro-4-methylquinoline

aniline

4-methyl-quinoline-2-sulfonic acid

4-methylquinolin-2-ol

Downstream raw materials:

(1,4-dimethyl-1H-[2]quinolylidene)-phenyl-amine; hydriodide

Refernces

• 1、 Zhang, Xi,Wang, Tong-Lin,Huo, Cong-De,Wang, Xi-Cun,Quan, Zheng-Jun. "Base-controlled chemoselectivity reaction of vinylanilines with isothiocyanates for synthesis of quinolino-2-thione and 2-aminoquinoline derivatives". supporting information. p. 3114 - 3117. Retrieved 2018/03/28.
• 2、 Dhanabal,Sangeetha,Mohan. "Heteroatom directed photoannulation: synthesis of indoloquinoline alkaloids: cryptolepine, cryptotackieine, cryptosanguinolentine, and their methyl derivatives". . p. 6258 - 6263. Retrieved 2007/10/03.