4-methylamino-1-[3]pyridyl-butan-1-ol

Base Information

• Chemical Name: 4-methylamino-1-[3]pyridyl-butan-1-ol
• CAS No.: 2055-27-8
• Molecular Formula: C₁₀H₁₆N₂O
• Molecular Weight: 180.25
• Mol file: 2055-27-8.mol

Synonyms:

Chemical Property of 4-methylamino-1-[3]pyridyl-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylamino-1-[3]pyridyl-butan-1-ol

There total 8 articles about 4-methylamino-1-[3]pyridyl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pseudooxynicotine (2055-23-4) → 4-methylamino-1-[3]pyridyl-butan-1-ol (2055-27-8,76030-54-1) + nicotin (54-11-5) + D-nicotine (25162-00-9)

Guidance literature:

With Cp*Ir(biot-p-L)Cl; streptavidin S₁₁₂A-K₁₂₃₁T mutant; oxygen; sodium formate; In aq. buffer; at 37 ℃; pH=7.8; enantioselective reaction; Enzymatic reaction;

DOI:10.1038/nchem.1498

Reference yield:

Pseudooxynicotine (2055-23-4) → 4-methylamino-1-[3]pyridyl-butan-1-ol (2055-27-8,76030-54-1) + 3-(1-methyl-pyrrolidin-2-yl)-pyridine (22083-74-5)

Guidance literature:

With sodium tetrahydroborate; In water; pH 9.0;

Reference yield:

Pseudooxynicotine (2055-23-4) → C10H16N2O + (S)-4-methylamino-1-[3]pyridyl-butan-1-ol (2055-27-8,76030-54-1)

Guidance literature:

With streptavidin S₁₁₂G mutant; Cp*Ir(biot-p-L)Cl; oxygen; sodium formate; In aq. buffer; at 37 ℃; pH=7.8; Optical yield = 30 %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1038/nchem.1498

upstream raw materials:

(S)-2-methyl-6-[3]pyridyl-tetrahydro-[1,2]oxazine

trans-(S)-nicotine N-1'-oxide

nicotin

Pseudooxynicotine

Downstream raw materials:

(E)-4-(methyl-propenyl-amino)-1-pyridin-3-yl-butan-1-ol

3-(1-methyl-pyrrolidin-2-yl)-pyridine

methyl-(4-pyridin-3-yl-but-3-enyl)-amine

Refernces

• 1、 Brandaenge, Svante,Lindblom, Lars,Pilotti, Ake,Rodriguez, Benito. "Ring-Chain Tautomerism of Pseudooxynicotine and Some Other Iminium Compounds". . p. 617 - 622. Retrieved 2007/10/02.