5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline

Base Information

• Chemical Name: 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline
• CAS No.: 128589-58-2
• Molecular Formula: C₁₆H₁₁N₃O₂S
• Molecular Weight: 309.348
• Mol file: 128589-58-2.mol

Synonyms:

Chemical Property of 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline

There total 3 articles about 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5H-2,3-dihydro-3-hydroxy-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline (128589-56-0) → 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline (128589-58-2)

Guidance literature:

With trifluoroacetic acid; at 80 ℃; for 40h;

Reference yield:

3,4-dihydro-1H-quinazoline-2-thione (22820-08-2) → 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline (128589-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / ethanol / 3 h / Heating

2: trifluoroacetic acid (TFA) / 40 h / 80 °C

With trifluoroacetic acid; In ethanol;

Reference yield:

2-amino-1-benzylamine (4403-69-4) → 5H-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline (128589-58-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent

2: 70 percent / ethanol / 3 h / Heating

3: trifluoroacetic acid (TFA) / 40 h / 80 °C

With trifluoroacetic acid; In ethanol;

upstream raw materials:

5H-2,3-dihydro-3-hydroxy-3-(p-nitrophenyl)thiazolo<2,3-b>quinazoline

3,4-dihydro-1H-quinazoline-2-thione

2-amino-1-benzylamine

Refernces