2-methyl-3-carbonylaminopyridine

Base Information

• Chemical Name: 2-methyl-3-carbonylaminopyridine
• CAS No.: 153025-46-8
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• Mol file: 153025-46-8.mol

Synonyms:

Chemical Property of 2-methyl-3-carbonylaminopyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-3-carbonylaminopyridine

There total 1 articles about 2-methyl-3-carbonylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ethyl 2-methyl nicotinate (1721-26-2) + L-Phenylalaninol (3182-95-4) → 2-methyl-3-carbonylaminopyridine (153025-46-8)

Guidance literature:

at 110 ℃; for 120h;

DOI:10.1016/S0040-4020(01)82373-5

Reference yield: 95.0%

2-methyl-3-carbonylaminopyridine (153025-46-8) + methyl iodide (74-88-4) → 1,2-dimethyl-3-carbonylaminopyridinium iodide

Guidance literature:

In acetonitrile; for 12h; Heating;

DOI:10.1016/S0040-4020(01)82373-5

Reference yield:

2-methyl-3-carbonylaminopyridine (153025-46-8) → 1,2-dimethyl-3-carbonylamino-1,4-dihydropyridine

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / acetonitrile / 12 h / Heating

2: 49 percent / Na₂S₂O₄, Na₂CO₃ / H₂O; CH₂Cl₂ / 0.33 h / 50 °C

With sodium dithionite; sodium carbonate; In dichloromethane; water; acetonitrile;

DOI:10.1016/S0040-4020(01)82373-5

upstream raw materials:

ethyl 2-methyl nicotinate

L-Phenylalaninol