3-methyl-3,4-dihydro-2H-1,3-benzoxazine

Base Information

• Chemical Name: 3-methyl-3,4-dihydro-2H-1,3-benzoxazine
• CAS No.: 113708-92-2
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.192
• Mol file: 113708-92-2.mol

Synonyms:

Chemical Property of 3-methyl-3,4-dihydro-2H-1,3-benzoxazine

Chemical Property:

• Vapor Pressure: 0.138mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-3,4-dihydro-2H-1,3-benzoxazine

There total 20 articles about 3-methyl-3,4-dihydro-2H-1,3-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-nitrophenoxy)-propan-2-one (5330-66-5) → (RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine (32329-20-7,113708-92-2)

Guidance literature:

With hydrogen; sodium hydroxide; Amperkat SK Ni-Mo 3706 from HC Starck; In methanol; toluene; at 40 ℃; for 1h; under 165017 Torr; pH=8 - 9; Product distribution / selectivity; Autoclave;

Reference yield: 92.0%

1-(2-aminophenoxy)propan-2-ol (854666-04-9) → (RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine (32329-20-7,113708-92-2)

Guidance literature:

With chloro(p-cymene)[(S)-2-(2-(diphenylphosphanyl)-phenyl)-4-phenyl-4,5-dihydrooxazole]ruthenium(II) chloride; potassium tert-butylate; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.6b00175

Reference yield: 92.0%

C14H19NO4 → (RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine (32329-20-7,113708-92-2)

Guidance literature:

With triethylsilane; aluminium(III) triflate; In acetonitrile; at 80 ℃; for 0.166667h;

DOI:10.1021/jo501824z

upstream raw materials:

1-(2-nitrophenoxy)-propan-2-one

N-(1-Methyl-2-phenoxy-ethyl)-hydroxylamine

C₁₁H₁₅NO₃

hydrogenchloride

Downstream raw materials:

N-[N'-tosyl-(2S)-propyl]-(3R)-2,3-dihydro-3-methyl-4H-1,4-benzoxazine

4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine

(3S)-2,3-dihydro-3-methyl-N-[N-phthaloyl-(2S)-2-phenylglycyl]-4H-1,4-benzoxazine

(2R)-2-methyl-1-[N-phthaloyl-3-cyclohexyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline