1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Base Information

• Chemical Name: 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>
• CAS No.: 137016-68-3
• Molecular Formula: C₅₂H₅₂Cl₄N₃O₁₀PSi
• Molecular Weight: 1079.87
• Mol file: 137016-68-3.mol

Synonyms:

Chemical Property of 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate>

There total 7 articles about 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6-dichlorobenzimidazole (6478-73-5) → 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (137016-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 20 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol;

DOI:10.1016/0008-6215(92)84178-U

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) → 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (137016-68-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 20 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol;

DOI:10.1016/0008-6215(92)84178-U

Reference yield:

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydrofuran-3,4-diyl diacetate (108126-17-6,443678-71-5) → 1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2,5-dichlorophenyl 2-(4-nitrophenyl)ethyl phosphate> (137016-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOMe / methanol

2: 87 percent / pyridine / Ambient temperature

3: 20 percent / pyridine / 18 h / Ambient temperature

With pyridine; sodium methylate; In methanol;

DOI:10.1016/0008-6215(92)84178-U

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

5,6-dichlorobenzimidazole

5,6-dichloro-1-β-D-ribobenzimidazole

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)tetrahydrofuran-3,4-diyl diacetate

Downstream raw materials:

1-(2-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-2-(4-nitrophenyl)ethyl>->5'>-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

1-(2-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 3'-<2-(4-nitrophenyl)ethyl triethylammonium phosphate>