2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

Base Information

Chemical Name:2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate
CAS No.:104754-42-9
Molecular Formula:C₁₃H₁₇NO₆S
Molecular Weight:315.347
Hs Code.:

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Chemical Property of 2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

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Technology Process of 2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

There total 6 articles about 2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 104754-41-8
2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol

: 124-63-0
methanesulfonyl chloride

: 104754-42-9
2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1016/S0040-4020(01)96774-2

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 104754-42-9
2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / sodium cyanoborohydride, 2N HCl / methanol / 2 h

2: 95 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

3: 97 percent / Ventron 50percent sodium hydride-oil dispersion / diethyl ether; dimethylformamide / Ambient temperature

4: 42 percent / H₂ / 10percent Pd-C / ethyl acetate / 1 h

5: 46 percent / 0.91M BF₃ / tetrahydrofuran / Ambient temperature

6: 83 percent / pyridine / Ambient temperature

With pyridine; hydrogenchloride; Ventron 50percent sodium hydride-oil dispersion; boron trifluoride; hydrogen; sodium cyanoborohydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96774-2

Reference yield:

: 51307-59-6
N-(4-methoxybenzyl)hydroxylamine

: 104754-42-9
2-(p-methoxybenzyl)-3-oxo-5-izoxazolidinemethanol methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 97 percent / Ventron 50percent sodium hydride-oil dispersion / diethyl ether; dimethylformamide / Ambient temperature

3: 42 percent / H₂ / 10percent Pd-C / ethyl acetate / 1 h

4: 46 percent / 0.91M BF₃ / tetrahydrofuran / Ambient temperature

5: 83 percent / pyridine / Ambient temperature

With pyridine; Ventron 50percent sodium hydride-oil dispersion; boron trifluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96774-2