4-(4-Methoxyphenoxy)but-2-yn-1-ol

Base Information

Chemical Name:4-(4-Methoxyphenoxy)but-2-yn-1-ol
CAS No.:105630-27-1
Molecular Formula:C11H12O3
Molecular Weight:192.214
Hs Code.:
DSSTox Substance ID:DTXSID60544773
Wikidata:Q82422035
Mol file:105630-27-1.mol

Synonyms:4-(4-Methoxyphenoxy)but-2-yn-1-ol;105630-27-1;DTXSID60544773

Suppliers and Price of 4-(4-Methoxyphenoxy)but-2-yn-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(4-Methoxyphenoxy)but-2-yn-1-ol

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:192.078644241
Heavy Atom Count:14
Complexity:205

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)OCC#CCO

Technology Process of 4-(4-Methoxyphenoxy)but-2-yn-1-ol

There total 3 articles about 4-(4-Methoxyphenoxy)but-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13280-07-4
4-chlorobut-2-yn-1-ol

: 150-76-5
4-methoxy-phenol

: 105630-27-1
4-(4-methoxyphenoxy)but-2-yn-1-ol

Guidance literature:: With potassium hydroxide; for 6h; Heating;
DOI:10.1080/00397919808004939

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 17061-86-8
1-methoxy-4-(2-propynyloxy)benzene

: 105630-27-1
4-(4-methoxyphenoxy)but-2-yn-1-ol

Guidance literature:: 1-methoxy-4-(2-propynyloxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

formaldehyd; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;
DOI:10.1039/c6md00406g

Reference yield:

: 150-76-5
4-methoxy-phenol

: 105630-27-1
4-(4-methoxyphenoxy)but-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 1.5 h / -78 - 20 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/c6md00406g