(1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one

Base Information

• Chemical Name: (1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one
• CAS No.: 69283-56-3
• Molecular Formula: C₂₃H₃₀ClFO₆
• Molecular Weight: 456.939

Synonyms:

Chemical Property of (1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one

There total 1 articles about (1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + 21-chloro-9-fluoro-11β-hydroxy-pregna-1,4,16-triene-3,20-dione (69283-83-6) → (1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one (69283-56-3)

Guidance literature:

With dimethylsulfide; ozone; Multistep reaction; 1.) dichloromethane-ethanol (2:1), -78 deg C; 2.) ambient temp.;

DOI:10.1021/jo00317a031

Reference yield: 70.0%

(1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one (69283-56-3) + isopropyl alcohol (67-63-0,8013-70-5) → 21-chloro-9-fluoro-11β-hydroxy-16β,17a-bis(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione (69283-64-3) + 21-chloro-9-fluoro-11β,17a-dihydroxy-16β-(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione (69503-79-3)

Guidance literature:

toluene-4-sulfonic acid; for 84h; Ambient temperature; dilute soln.;

DOI:10.1021/jo00317a031

Reference yield: 35.0%

(1S,3R,4aS,4bS,10aS,10bR,11S,12aS)-1-(2-Chloro-acetyl)-3-ethoxy-10b-fluoro-1,11-dihydroxy-10a,12a-dimethyl-1,3,4,4a,4b,5,6,10a,10b,11,12,12a-dodecahydro-2-oxa-chrysen-8-one (69283-56-3) + isopropyl alcohol (67-63-0,8013-70-5) → (8S,9R,10S,11S,13S,14S)-16-Chloromethyl-9-fluoro-11,16-dihydroxy-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-15-carbaldehyde (75961-84-1) + 21-chloro-9-fluoro-11β-hydroxy-16β,17a-bis(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione (69283-64-3) + 21-chloro-9-fluoro-11β,17a-dihydroxy-16β-(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione (69503-79-3)

Guidance literature:

toluene-4-sulfonic acid; for 0.5h; Heating; reflux;

DOI:10.1021/jo00317a031

upstream raw materials:

ethanol

21-chloro-9-fluoro-11β-hydroxy-pregna-1,4,16-triene-3,20-dione

Downstream raw materials:

(8S,9R,10S,11S,13S,14S)-16-Chloromethyl-9-fluoro-11,16-dihydroxy-10,13-dimethyl-3,17-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-15-carbaldehyde

21-chloro-9-fluoro-11β-hydroxy-16β,17a-bis(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione

21-chloro-9-fluoro-11β,17a-dihydroxy-16β-(1-methylethoxy)-D-homo-17-oxapregna-1,4-diene-3,20-dione

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