2-Bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

Base Information

Chemical Name:2-Bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene
CAS No.:170100-73-9
Molecular Formula:C₁₅H₂₁BrO
Molecular Weight:297.235
Hs Code.:
DSSTox Substance ID:DTXSID201162847

Synonyms:SCHEMBL5366510;WIFNLUBZVRKEHQ-UHFFFAOYSA-N;DTXSID201162847;2-bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene;3-bromo-2-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene;6-Bromo-1,2,3,4-tetrahydro-7-methoxy-1,1,4,4-tetramethylnaphthalene;170100-73-9

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:296.07758
Heavy Atom Count:17
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(CCC(C2=CC(=C(C=C21)OC)Br)(C)C)C

Technology Process of 2-Bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

There total 1 articles about 2-Bromo-3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: E,E-3-Methyl-5-[2-(3-methoxy-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-cyclohexen-1-yl]-2,4-pentadienoic Acid

: 170100-73-9
2-bromo-3-methoxy-5,5,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

Guidance literature:

Reference yield:

: 170100-73-9
2-bromo-3-methoxy-5,5,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

: 365430-77-9
ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / t-BuLi / tetrahydrofuran / -78 °C

2: SOCl₂ / Heating

3: 85 percent / pyridine / CH₂Cl₂

4: 92 percent / BBr₃ / CH₂Cl₂ / -78 - -25 °C

With pyridine; thionyl chloride; tert.-butyl lithium; boron tribromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(02)00647-9

Reference yield:

: 170100-73-9
2-bromo-3-methoxy-5,5,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / t-BuLi / tetrahydrofuran / -78 °C

2: SOCl₂ / Heating

3: 85 percent / pyridine / CH₂Cl₂

4: 92 percent / BBr₃ / CH₂Cl₂ / -78 - -25 °C

5: 70 percent / SOCl₂ / CH₂Cl₂; diethyl ether / 25 °C

6: NaOH / ethanol

With pyridine; sodium hydroxide; thionyl chloride; tert.-butyl lithium; boron tribromide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00647-9