ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Base Information

Chemical Name:ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate
CAS No.:365430-77-9
Molecular Formula:C₂₄H₂₇F₂NO₄
Molecular Weight:431.479
Hs Code.:

Synonyms:ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

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Chemical Property of ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

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Technology Process of ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

There total 5 articles about ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 528837-99-2
2,6-difluoro-4-[(3-methoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoic acid ethyl ester

: 365430-77-9
ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - -25 ℃;
DOI:10.1016/S0960-894X(02)00647-9

Reference yield:

: 75-03-6
ethyl iodide

: 321995-62-4
2,6-difluoro-4-[(3-hydroxy-5,5,8,8,tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)-amino]-benzoic Acid

: 365430-77-9
ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Guidance literature:: With potassium carbonate; In acetone;

Reference yield:

: 170100-73-9
2-bromo-3-methoxy-5,5,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

: 365430-77-9
ethyl 2,6-difluoro-4-[(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / t-BuLi / tetrahydrofuran / -78 °C

2: SOCl₂ / Heating

3: 85 percent / pyridine / CH₂Cl₂

4: 92 percent / BBr₃ / CH₂Cl₂ / -78 - -25 °C

With pyridine; thionyl chloride; tert.-butyl lithium; boron tribromide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(02)00647-9