2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

Base Information

Chemical Name:2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt
CAS No.:1006038-82-9
Molecular Formula:C₃H₉N*C₃₄H₃₂ClNO₄S
Molecular Weight:645.263
Hs Code.:

2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

Synonyms:

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Chemical Property of 2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

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Technology Process of 2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

There total 3 articles about 2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851755-56-1
[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid

: 75-31-0
isopropylamine

: 1006038-82-9
2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

Guidance literature:: [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid; isopropylamine; In ethyl acetate; at 20 - 25 ℃; for 37h; Inert atmosphere;

Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 880769-25-5
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

: 75-31-0
isopropylamine

: 162515-68-6
1-(sulfanylmethyl)cyclopropaneacetic acid

: 1006038-82-9
2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

Guidance literature:: 1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 0 ℃; for 2h;

methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate; In N,N-dimethyl-formamide; at -5 - 0 ℃; for 25h;

isopropylamine; With water; tartaric acid; sodium chloride; more than 3 stages;

Reference yield:

: 162515-68-6
1-(sulfanylmethyl)cyclopropaneacetic acid

: 1006038-82-9
2-[1-[1(R)-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propylsulfanylmethyl]cyclopropyl]acetic acid isopropyl amine salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / -5 - 0 °C / Inert atmosphere

1.2: 25 h / -5 - 0 °C / Inert atmosphere

2.1: ethyl acetate / 37 h / 20 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

With sodium hydride; In ethyl acetate; N,N-dimethyl-formamide;