Benzoic acid, 2-[(3S)-3-chloro-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl ]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 2-[(3S)-3-chloro-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl ]-, methyl ester
CAS No.:880769-25-5
Molecular Formula:C28H23Cl2NO2
Molecular Weight:476.402
Hs Code.:

Synonyms:montelukast DPA salt;methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2yl)ethenyl]phenyl]-3-chloropropyl]benzoate;Methyl 2-[(3S)-[3-[(2E)-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 2-[(3S)-3-chloro-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl ]-, methyl ester

Chemical Property:

Boiling Point:626.5±55.0 °C(Predicted)
PSA：39.19000
Density:1.280±0.06 g/cm3(Predicted)
LogP:7.75790

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Benzoic acid, 2-[(3S)-3-chloro-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl ]-, methyl ester

There total 1 articles about Benzoic acid, 2-[(3S)-3-chloro-3-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl ]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 181139-72-0
methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate

: 880769-25-5
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 8 - 25 ℃; for 2.91667h;

Reference yield: 65.0%

: 880769-25-5
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

: 676-58-4
methylmagnesium chloride

: 880769-28-8
2-(2-(3(S)-chloro-3-(3-(2-(7-chloro-2-quinolinyl)-(E)ethenyl)phenyl)propyl)phenyl)-2-propanol

Guidance literature:: methylmagnesium chloride; With cerium(III) chloride; In tetrahydrofuran; at -5 - 0 ℃; for 2.7h;

methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate; In tetrahydrofuran; toluene; at 0 - 5 ℃; for 2h;

Reference yield: 52.8%

: 880769-25-5
methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate

: 101-83-7
N-cyclohexyl-cyclohexanamine

: 162515-68-6
1-(sulfanylmethyl)cyclopropaneacetic acid

: 2-(3(R)-(1-carboxymethyl-cyclopropylmethylsulfanyl)-3-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester dicyclohexyl-amine

Guidance literature:: 1-(sulfanylmethyl)cyclopropaneacetic acid; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 0 ℃; for 2h;

methyl 2-[(3S)-[3-[(2E)-(7-chloro quinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]benzoate; In N,N-dimethyl-formamide; at -5 - 0 ℃; for 25h;

N-cyclohexyl-cyclohexanamine; In ethyl acetate; at 20 - 25 ℃; for 37.5h;