Propargyl-PEG13-alcohol

Base Information

• Chemical Name: Propargyl-PEG13-alcohol
• CAS No.: 1036204-61-1
• Molecular Formula: C₂₇H₅₂O₁₃
• Molecular Weight: 584.702
• Mol file: 1036204-61-1.mol

Synonyms:

Chemical Property of Propargyl-PEG13-alcohol

Chemical Property:

• Boiling Point: 613.0±50.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• Density: 1.099±0.06 g/cm3(Predicted)
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

99.3% ^*data from raw suppliers

Propargyl-peg13-alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG13-alcohol can reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form stable triazole linkage. The hydrophilic PEG units increase the water-solubility of the molecule.
• Uses: Propargyl-peg13-alcohol is used as a reactant in the synthesis of fluorescent probes targeting β-amyloid plaques.

Technology Process of Propargyl-PEG13-alcohol

There total 10 articles about Propargyl-PEG13-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

dodecaethylene glycol (6790-09-6) + propargyl bromide (106-96-7) → C27H52O13 (1036204-61-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2008.03.130

Reference yield: 35.0%

C46H66O13 → C27H52O13 (1036204-61-1)

Guidance literature:

With toluene-4-sulfonic acid; In methanol;

DOI:10.1002/cbic.201900341

Reference yield:

Tetraethylene glycol (112-60-7) + toluene-4-sulfonic acid 2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl ester (1351556-82-5) → C27H52O13 (1036204-61-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

DOI:10.1002/chem.201802824

upstream raw materials:

dodecaethylene glycol

propargyl bromide

Tetraethylene glycol

toluene-4-sulfonic acid 2-(2-{2-[2-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl ester