Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

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Chemical Name:Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester
CAS No.:82206-62-0
Molecular Formula:C₆₅H₉₅N₂O₁₄P
Molecular Weight:1159.45
Hs Code.:

Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

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Chemical Property of Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

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Technology Process of Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

There total 2 articles about Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 82206-62-0
Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (C₂H₅)3N / CH₂Cl₂ / 2 h / 25 °C

2: (C₂H₅)3N / CH₂Cl₂ / 1.) 25 deg C, 10 min, 2.) 0 deg C, 16 h, 3.) 25 deg C, 2 h

With triethylamine; In dichloromethane;
DOI:10.1055/s-1982-29813

Reference yield:

: 60562-16-5,56270-93-0
1,2-dimyristoyl-sn-glycerol

: 62930-00-1
O^3'-(4,5-dimethyl-2-oxo-2λ⁵-[1,3,2]dioxaphosphol-2-yl)-O^5'-(4-methoxy-trityl)-thymidine

: 82206-62-0
Tetradecanoic acid (R)-2-[[(2R,3S,5R)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-(1-methyl-2-oxo-propoxy)-phosphoryloxy]-1-tetradecanoyloxymethyl-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; 1.) 25 deg C, 10 min, 2.) 0 deg C, 16 h, 3.) 25 deg C, 2 h;
DOI:10.1055/s-1982-29813