Technology Process of Z-Gln-Aib-Ile-Aib-Gly-Leu-Aib-OPac
There total 13 articles about Z-Gln-Aib-Ile-Aib-Gly-Leu-Aib-OPac which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
In
N,N-dimethyl-formamide;
for 48h;
Ambient temperature;
DOI:10.1248/cpb.38.2997
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 40 h / Ambient temperature
2: 1) H2, 2) 1 N HCl / 1) 10percent Pd-C / 1) 90percent aq. MeOH
3: 78 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 40 h / Ambient temperature
4: 68 percent / 1 N NaOH / methanol / below 35 deg C
5: 82 percent / triethylamine / dimethylformamide / 24 h
6: 95 percent / 30percent HBr in AcOH / acetic acid / 2 h
7: 52 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 48 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; hydrogen bromide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2997
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 54 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 40 h / Ambient temperature
2: 1) H2, 2) 1 N HCl / 1) 10percent Pd-C / 1) 90percent aq. MeOH
3: 82 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 72 h / Ambient temperature
4: 79 percent / 1 N NaOH / methanol / below 35 deg C
5: 52 percent / 1-hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide, triethylamine / dimethylformamide / 48 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.2997
