Technology Process of trans-2-(2,3-dichlorophenyl)cyclopropylamine*HCl
There total 5 articles about trans-2-(2,3-dichlorophenyl)cyclopropylamine*HCl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
at 100 ℃;
Yield given;
DOI:10.1021/jm9507136
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / NBu4Cl, Pd(OAc)2, K2CO3 / dimethylformamide / 19 h / 50 °C
2: Pd(OAc)2 / diethyl ether; CH2Cl2 / 1.5 h / -10 °C
3: 2 M aq. NaOH / methanol / 2 h / Ambient temperature
4: diphenyl phosphorazidate, triethylamine / 42 h / 90 °C
5: 1 M aq. HCl / 100 °C
With
hydrogenchloride; palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; tetrabutyl-ammonium chloride; potassium carbonate; triethylamine;
In
methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9507136
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Pd(OAc)2 / diethyl ether; CH2Cl2 / 1.5 h / -10 °C
2: 2 M aq. NaOH / methanol / 2 h / Ambient temperature
3: diphenyl phosphorazidate, triethylamine / 42 h / 90 °C
4: 1 M aq. HCl / 100 °C
With
hydrogenchloride; palladium diacetate; sodium hydroxide; diphenyl phosphoryl azide; triethylamine;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm9507136
