(2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Base Information

• Chemical Name: (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid
• CAS No.: 77341-73-2
• Molecular Formula: C₁₁H₈ClNO₃*C₁₉H₁₈ClN₃O₅S
• Molecular Weight: 673.53

Synonyms:

Chemical Property of (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

Chemical Property:

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Technology Process of (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

There total 2 articles about (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Aminopenicillanic Acid (551-16-6) → (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (77341-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / CH₂Cl₂

2: 1.) ClSPO, CH₂Cl₂ 2.) CH₂Cl₂, 0 - 5 gradC, 100 min

With TEA; In dichloromethane;

DOI:10.1016/S0040-4039(00)93682-7

Reference yield:

6-aminopenicillanic acid trimethylsilyl ester (1025-55-4) + triethylammonium salt of the 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylic acid → (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 3-(2-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid (77341-73-2)

Guidance literature:

Yield given. Multistep reaction; 1.) ClSPO, CH₂Cl₂ 2.) CH₂Cl₂, 0 - 5 gradC, 100 min;

DOI:10.1016/S0040-4039(00)93682-7

upstream raw materials:

6-aminopenicillanic acid trimethylsilyl ester

6-Aminopenicillanic Acid

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