10-bisbenzyloxyphosphinoyloxydecanoic acid

Base Information

• Chemical Name: 10-bisbenzyloxyphosphinoyloxydecanoic acid
• CAS No.: 153487-89-9
• Molecular Formula: C₂₄H₃₃O₆P
• Molecular Weight: 448.496
• Mol file: 153487-89-9.mol

Synonyms:

Chemical Property of 10-bisbenzyloxyphosphinoyloxydecanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-bisbenzyloxyphosphinoyloxydecanoic acid

There total 2 articles about 10-bisbenzyloxyphosphinoyloxydecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10-hydroxydecanoic acid (1679-53-4) + dibenzyl phosphochloridate (538-37-4) → 10-bisbenzyloxyphosphinoyloxydecanoic acid (153487-89-9)

Guidance literature:

With pyridine; In tetrachloromethane; at 4 ℃; for 20h; Yield given;

Reference yield:

Dibenzyl phosphite (17176-77-1) → 10-bisbenzyloxyphosphinoyloxydecanoic acid (153487-89-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SO₂Cl₂ / CCl₄ / 0.17 h

2: pyridine / CCl₄ / 20 h / 4 °C

With pyridine; sulfuryl dichloride; In tetrachloromethane;

Reference yield:

10-bisbenzyloxyphosphinoyloxydecanoic acid (153487-89-9) → N-(4-(N-(3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)-10-(phosphooxy)decanamido)benzoyl)-L-glutamic acid trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride / 0.08 h / -20 °C

2: N,N-dimethyl-acetamide / 1 h / Ambient temperature

3: H₂ / 5percent Pd/C / methanol / 40 h

With oxalyl dichloride; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide;

upstream raw materials:

10-hydroxydecanoic acid

dibenzyl phosphochloridate

Dibenzyl phosphite

Downstream raw materials:

N-(4-(10-((bis(benzyloxy)phosphinoyl)oxy)-N-(3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)decanamido)benzoyl)-L-glutamic acid

Refernces