Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate

Base Information

• Chemical Name: Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate
• CAS No.: 81960-72-7
• Molecular Formula: C₁₂H₁₁N₃O₃
• Molecular Weight: 245.238
• Mol file: 81960-72-7.mol

Synonyms:

Chemical Property of Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate

There total 3 articles about Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

CYANAMID (420-04-2) + E,Z-Methyl 2-Cyano-3-methoxy-3-phenylpropenoate (59551-70-1) → Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate (81960-72-7)

Guidance literature:

With hydrogenchloride; sodium methylate; In methanol; for 8h; Heating;

Reference yield:

methyl 3-cyanamino-2-cyano-3-phenylpropenoate sodium salt → Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate (81960-72-7)

Guidance literature:

With hydrogenchloride; In water; for 2h; Ambient temperature;

Reference yield:

methyl N-cyanobenzenecarboximidoate (6041-23-2) → Z-Methyl 3-<(Aminocarbonyl)amino>-2-cyano-3-phenylpropenoate (81960-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / sodium methoxide / methanol / 0.5 h / Ambient temperature

2: 3N-HCl / H₂O / 2 h / Ambient temperature

With hydrogenchloride; sodium methylate; In methanol; water;

upstream raw materials:

CYANAMID

E,Z-Methyl 2-Cyano-3-methoxy-3-phenylpropenoate

methyl N-cyanobenzenecarboximidoate

Downstream raw materials:

2,4-dioxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Refernces

• 1、 Perez, Miguel A.,Soto, Jose L.. "Synthesis of 2-Alkoxy-6-aryl-5-cyano-4(3H)-pyrimidinones". . p. 177 - 179. Retrieved 2007/10/02.