(alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester

Base Information

• Chemical Name: (alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester
• CAS No.: 386230-13-3
• Molecular Formula: C₄₇H₅₀ClNO₁₄
• Molecular Weight: 888.365
• Nikkaji Number: J1.607.637F

Synonyms:(alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester

Chemical Property of (alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 15
• Exact Mass: 887.2919830
• Heavy Atom Count: 63
• Complexity: 1820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)CCl)C)O
• Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC(=O)CCl)C)O

Technology Process of (alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester

There total 3 articles about (alphaR,betaS)-alpha-Hydroxy-beta-(benzoylamino)benzenepropionic acid 1,10beta-dihydroxy-2alpha-(benzoyloxy)-4-acetoxy-7beta-(chloroacetoxy)-9-oxo-5beta,20-epoxytaxa-11-ene-13alpha-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-(tert-butyldimethylsilyl)-7-chloroacetyl-10-deacetylpaclitaxel (455252-53-6) → 7-chloroacetyl-10-deacetylpaclitaxel (386230-13-3)

Guidance literature:

With pyridine; hydrogen fluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/np010552a

Reference yield:

2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel (162375-26-0) → 7-chloroacetyl-10-deacetylpaclitaxel (386230-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h

2: HF; pyridine / tetrahydrofuran / 20 °C

With pyridine; hydrogen fluoride; In tetrahydrofuran;

DOI:10.1021/np010552a

Reference yield:

2',7-bis-monochloroacetyl-10-deacetylpaclitaxel → 7-chloroacetyl-10-deacetylpaclitaxel (386230-13-3)

Guidance literature:

With methanol; at 20 ℃; Solvolysis;

DOI:10.1016/S0040-4039(01)01643-4

upstream raw materials:

2'-O-(tert-butyldimethylsilyl)-7-chloroacetyl-10-deacetylpaclitaxel

2'-O-(tert-butyldimethylsilyl)-10-deacetylpaclitaxel

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 386230-13-3 7-chloroacetyl-10-deacetylpaclitaxel

Send

Send

Metric Ton KG G Pound L ML

Send

Send