2,3-diacetoxy-5-chlorophenylacetic acid

Base Information

• Chemical Name: 2,3-diacetoxy-5-chlorophenylacetic acid
• CAS No.: 86232-51-1
• Molecular Formula: C₁₂H₁₁ClO₆
• Molecular Weight: 286.669
• Mol file: 86232-51-1.mol

Synonyms:

Chemical Property of 2,3-diacetoxy-5-chlorophenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-diacetoxy-5-chlorophenylacetic acid

There total 14 articles about 2,3-diacetoxy-5-chlorophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-hydroxy-3-methoxy-benzaldehyde (7740-05-8) → 2,3-diacetoxy-5-chlorophenylacetic acid (86232-51-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

2: 75 percent / K₂CO₃ / acetone / 5 h / Heating

3: 77 percent / KMnO₄ / H₂O / 5 h / Heating

4: SOCl₂ / 2 h / Heating

5: diethyl ether / 10 h / 20 °C

6: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

7: 88 percent / AlBr₃ / benzene / 3 h / Heating

8: 81 percent / 10percent aq. NaOH / 0.33 h

With potassium hydroxide; sodium hydroxide; potassium permanganate; thionyl chloride; aluminum tri-bromide; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; diethyl ether; water; acetone; benzene;

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2,3-diacetoxy-5-chlorophenylacetic acid (86232-51-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 45 percent / chlorine / acetic acid / 5 h / 20 °C

2: 1) 99percent hydrazine hydrate, 2) KOH / 1) reflux, 5 h, 2) reflux, 5 h

3: 75 percent / K₂CO₃ / acetone / 5 h / Heating

4: 77 percent / KMnO₄ / H₂O / 5 h / Heating

5: SOCl₂ / 2 h / Heating

6: diethyl ether / 10 h / 20 °C

7: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

8: 88 percent / AlBr₃ / benzene / 3 h / Heating

9: 81 percent / 10percent aq. NaOH / 0.33 h

With potassium hydroxide; sodium hydroxide; potassium permanganate; thionyl chloride; aluminum tri-bromide; chlorine; potassium carbonate; hydrazine hydrate; silver(l) oxide; In 1,4-dioxane; diethyl ether; water; acetic acid; acetone; benzene;

Reference yield:

3-methoxy-2-hydroxy-5-chlorotoluene (86232-26-0) → 2,3-diacetoxy-5-chlorophenylacetic acid (86232-51-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 75 percent / K₂CO₃ / acetone / 5 h / Heating

2: 77 percent / KMnO₄ / H₂O / 5 h / Heating

3: SOCl₂ / 2 h / Heating

4: diethyl ether / 10 h / 20 °C

5: 45 percent / silver oxide / dioxane; H₂O / 1 h / 95 °C

6: 88 percent / AlBr₃ / benzene / 3 h / Heating

7: 81 percent / 10percent aq. NaOH / 0.33 h

With sodium hydroxide; potassium permanganate; thionyl chloride; aluminum tri-bromide; potassium carbonate; silver(l) oxide; In 1,4-dioxane; diethyl ether; water; acetone; benzene;

upstream raw materials:

5-chloro-2-hydroxy-3-methoxy-benzaldehyde

5-chloro-2,3-dimethoxybenzaldehyde

3-Methyl-4,5-dimethoxyaniline

5-chloro-2,3-dimethoxybenzoyl chloride