tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

Base Information

Chemical Name:tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate
CAS No.:1287261-28-2
Molecular Formula:C₃₀H₄₂N₄O₇
Molecular Weight:570.686
Hs Code.:

tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

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Chemical Property of tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

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Technology Process of tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

There total 12 articles about tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1287261-59-9
methyl 2-((S)-2-((2S,3S)-2-(tert-butoxycarbonylamino)-3-methylpentyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

: 1287261-28-2
tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

Guidance literature:: With hydroxylamine potassium salt; In methanol; for 0.5h;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-63-0
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-28-2
tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; trifluoroacetic acid / dichloromethane

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

3: hydroxylamine potassium salt / methanol / 0.5 h

With hydroxylamine potassium salt; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-39-0
(S)-tert-butyl 7-hydroxy-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-28-2
tert-butyl (2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-(4-methoxyphenylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methylpentan-2-yl carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: triethylamine; trifluoroacetic acid / dichloromethane

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

4: hydroxylamine potassium salt / methanol / 0.5 h

With hydroxylamine potassium salt; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z