methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

Base Information

Chemical Name:methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate
CAS No.:84390-88-5
Molecular Formula:C₂₅H₂₉ClO₇
Molecular Weight:476.954
Hs Code.:

Synonyms:

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Chemical Property of methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

Chemical Property:

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Technology Process of methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

There total 14 articles about methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 33234-36-5
2-chloro-3-methoxybenzoic acid

: 84390-87-4
(1,4-Dimethoxy-6-methoxymethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid methyl ester

: 84390-88-5
methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

Guidance literature:: With trifluoroacetic anhydride; at 60 ℃; for 144h;

Reference yield:

: 41098-99-1
1,2,3,4-tetrahydro-5,8-dimethoxy-4-oxonaphthalene-2-carboxylic acid

: 84390-88-5
methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

Guidance literature:: Multi-step reaction with 15 steps

1: 85 percent / HCl / 1.5 h / Heating

2: 63 percent / BCl₃ / CH₂Cl₂ / 0.17 h / Ambient temperature

3: 81 percent / conc.HCl, H₂ / platinum oxide / methanol

4: 71 percent / K₂CO₃ / acetone / 7 h / 70 °C

5: 96 percent / LiAlH₄ / diethyl ether / 2 h / Heating

6: 94 percent / dimethylaniline / 5 h / 200 °C

7: 92 percent / K₂CO₃ / acetone / 50 h / Heating

8: NaH / dimethylformamide / 1.5 h / 60 °C

9: osmium tetraoxide, sodium metaperiodate / dioxane; ethyl acetate; H₂O / 20 h / Ambient temperature

10: 92 percent / LiAlH₄ / diethyl ether / 1 h / 50 °C

11: PBr₃ / diethyl ether / 0.5 h / 0 °C

12: ethanol; H₂O / 2 h / Heating

13: 10M NaOH / ethanol / 7.5 h / Heating

14: thionyl chloride / 3 h / Ambient temperature

15: 47 percent / trifluoroacetic anhydride / 144 h / 60 °C

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; boron trichloride; phosphorus tribromide; sodium hydride; potassium carbonate; 2,3-Dimethylaniline; trifluoroacetic anhydride; platinum(IV) oxide; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 76117-16-3
methyl 1,2,3,4-tetrahydro-5,8-dimethoxy-4-oxonaphthalene-2-carboxylate

: 84390-88-5
methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-2-methoxymethyl-6-naphthylacetate

Guidance literature:: Multi-step reaction with 14 steps

1: 63 percent / BCl₃ / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 81 percent / conc.HCl, H₂ / platinum oxide / methanol

3: 71 percent / K₂CO₃ / acetone / 7 h / 70 °C

4: 96 percent / LiAlH₄ / diethyl ether / 2 h / Heating

5: 94 percent / dimethylaniline / 5 h / 200 °C

6: 92 percent / K₂CO₃ / acetone / 50 h / Heating

7: NaH / dimethylformamide / 1.5 h / 60 °C

8: osmium tetraoxide, sodium metaperiodate / dioxane; ethyl acetate; H₂O / 20 h / Ambient temperature

9: 92 percent / LiAlH₄ / diethyl ether / 1 h / 50 °C

10: PBr₃ / diethyl ether / 0.5 h / 0 °C

11: ethanol; H₂O / 2 h / Heating

12: 10M NaOH / ethanol / 7.5 h / Heating

13: thionyl chloride / 3 h / Ambient temperature

14: 47 percent / trifluoroacetic anhydride / 144 h / 60 °C

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; boron trichloride; phosphorus tribromide; sodium hydride; potassium carbonate; 2,3-Dimethylaniline; trifluoroacetic anhydride; platinum(IV) oxide; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;