2-Chloro-3-methoxybenzoic acid

Base Information

Chemical Name:2-Chloro-3-methoxybenzoic acid
CAS No.:33234-36-5
Molecular Formula:C8H7ClO3
Molecular Weight:186.595
Hs Code.:2918990090
European Community (EC) Number:627-671-8
DSSTox Substance ID:DTXSID80584732
Nikkaji Number:J2.185.342I
Wikidata:Q72453041
Mol file:33234-36-5.mol

Synonyms:2-Chloro-3-methoxybenzoic acid;33234-36-5;MFCD07784399;Benzoic acid, 2-chloro-3-methoxy-;2-CHLORO-3-METHOXYBENZOICACID;COLUMBIANETINACETATE;SCHEMBL993218;2-Chloro-3-methoxy-benzoic acid;DTXSID80584732;VIUDWLLKFANPLX-UHFFFAOYSA-N;AMY39727;GEO-02916;TD1043;AKOS015889439;2-Chloro-3-methoxybenzoic acid, 97%;CS-W016878;AC-28680;AS-54699;SY045705;2-CHLORO-3-METHOXYBENZOIC ACID 97;EN300-379038;A856682;J-019101;Z1255461970

Suppliers and Price of 2-Chloro-3-methoxybenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-3-methoxybenzoic acid
50mg
$ 60.00

Sigma-Aldrich
2-Chloro-3-methoxybenzoic acid 97%
10g
$ 316.00

Sigma-Aldrich
2-Chloro-3-methoxybenzoic acid 97%
1g
$ 52.00

Crysdot
2-Chloro-3-methoxybenzoic acid 98%
5g
$ 200.00

Chemenu
2-Chloro-3-methoxybenzoic acid 95+%
5g
$ 224.00

Biosynth Carbosynth
2-Chloro-3-methoxybenzoic acid
2 g
$ 100.00

Biosynth Carbosynth
2-Chloro-3-methoxybenzoic acid
1 g
$ 65.00

Biosynth Carbosynth
2-Chloro-3-methoxybenzoic acid
25 g
$ 750.00

Biosynth Carbosynth
2-Chloro-3-methoxybenzoic acid
5 g
$ 200.00

Biosynth Carbosynth
2-Chloro-3-methoxybenzoic acid
10 g
$ 350.00

Total 33 raw suppliers

Chemical Property of 2-Chloro-3-methoxybenzoic acid

Chemical Property:

Vapor Pressure:0.00019mmHg at 25°C
Melting Point:161-165 °C
Refractive Index:1.562
Boiling Point:315 °C at 760 mmHg
PKA:2.84±0.25(Predicted)
Flash Point:144.3 °C
PSA：46.53000
Density:1.352 g/cm³
LogP:2.04680
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:186.0083718
Heavy Atom Count:12
Complexity:172

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-3-methoxybenzoic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC1=CC=CC(=C1Cl)C(=O)O

Technology Process of 2-Chloro-3-methoxybenzoic acid

There total 15 articles about 2-Chloro-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1984-59-4
2,3-dichloroanisole

: 2845-89-8
1-chloro-3-methoxy-benzene

: 766-51-8
2-Chloroanisole

: 3260-89-7
2-chloro-6-methoxybenzoic acid

: 33234-36-5
2-chloro-3-methoxybenzoic acid

Guidance literature:: With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 5 ℃; Yields of byproduct given; electrolysis (I=0.4 A);
DOI:10.1016/S0040-4020(01)86724-7

Reference yield: 47.0%

: 586-38-9
3-Methoxybenzoic acid

: 33234-36-5
2-chloro-3-methoxybenzoic acid

Guidance literature:: 3-Methoxybenzoic acid; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at 0 ℃; for 2h;

With hexachloroethane; In tetrahydrofuran; at 0 - 65 ℃; for 2.5h;

With hydrogenchloride; at 20 ℃;
DOI:10.1021/ol050761c

Reference yield:

: 5368-81-0
methyl 3-methoxybenzoate

: 33234-36-5
2-chloro-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: (nitration)

2: H₂ / Pd-C

3: (i) aq. HCl, NaNO₂, (ii) CuCl, aq. HCl

4: aq. NaOH

With sodium hydroxide; hydrogen; palladium on activated charcoal;