(S)-N-benzyloxythalidomide

Base Information

• Chemical Name: (S)-N-benzyloxythalidomide
• CAS No.: 169824-53-7
• Molecular Formula: C₂₀H₁₆N₂O₅
• Molecular Weight: 364.357
• Mol file: 169824-53-7.mol

Synonyms:

Chemical Property of (S)-N-benzyloxythalidomide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-benzyloxythalidomide

There total 2 articles about (S)-N-benzyloxythalidomide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) + (S)-1-benzyloxy-3-tertbutyloxycarbonylamino piperidine-2,6-dione hydrochloride → (S)-N-benzyloxythalidomide (169824-53-7)

Guidance literature:

With 4 A molecular sieve; triethylamine; In tetrahydrofuran; for 2h; Yield given; Heating;

DOI:10.1016/0957-4166(95)00155-I

Reference yield:

N-benzyloxyamine (622-33-3) + N-phthaloyl-L-glutamic anhydride (25830-77-7,3085-92-5) → (S)-N-benzyloxythalidomide (169824-53-7)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) RT, overnight, 2.) 2 days;

DOI:10.1016/0957-4166(95)00155-I

Reference yield: 89.0%

(S)-N-benzyloxythalidomide (169824-53-7) → (S)-N-hydroxythalidomide (170079-57-9,126663-38-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h;

DOI:10.1016/0957-4166(95)00155-I

upstream raw materials:

phthalic anhydride

N-benzyloxyamine

N-phthaloyl-L-glutamic anhydride

Downstream raw materials:

(S)-N-hydroxythalidomide