*,R^*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate

Base Information

• Chemical Name: *,R^*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate
• CAS No.: 101250-32-2
• Molecular Formula: C₂₃H₃₆N₂O₃S₂
• Molecular Weight: 452.682

Synonyms:

Chemical Property of *,R^*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of *,R^*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate

There total 7 articles about *,R^*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-4-methylpentanoic Acid (28659-87-2,42990-28-3,49628-52-6,42990-24-9) → *,R*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate (101250-32-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 50 percent / DCC, N,N-dimethyl-4-pyridinamine

2: 20 percent / NH₃ liquid

3: NaOH

4: TFA

5: 1H-benzotriazol-1-ol (HOBT), DCC

With dmap; sodium hydroxide; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1021/jm00156a012

Reference yield:

(S)-(+)-2-Pyrrolidinmethanthiol (85657-09-6) → *,R*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate (101250-32-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 percent / NH₃ liquid

2: NaOH

3: TFA

4: 1H-benzotriazol-1-ol (HOBT), DCC

With sodium hydroxide; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1021/jm00156a012

Reference yield:

2-bromo-4-methylpentanoic acid t-butyl ester (152624-22-1) → *,R*)>-phenylmethyl 2-<<<1-<<<2-(ethylthio)ethyl>amino>carbonyl>-3-methylbutyl>thio>methyl>-1-pyrrolidinecarboxylate (101250-32-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 20 percent / NH₃ liquid

2: NaOH

3: TFA

4: 1H-benzotriazol-1-ol (HOBT), DCC

With sodium hydroxide; ammonia; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1021/jm00156a012

upstream raw materials:

2-(ethylthio)ethylamine hydrochloride

(S)-2-((S)-1-Carboxy-3-methyl-butylsulfanylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester

2-Bromo-4-methylpentanoic Acid

(S)-(+)-2-Pyrrolidinmethanthiol

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